| 1. Round | 18/07/2021 | Rapid Bucureşti | - | Chindia Târgoviște | 1:0 | ||||
| 2. Round | 23/07/2021 | CS Mioveni | - | Rapid Bucureşti | 0:2 | ||||
| 3. Round | 30/07/2021 | Rapid Bucureşti | - | Farul Constanța | 0:0 | ||||
| 4. Round | 07/08/2021 | Argeș Pitești | - | Rapid Bucureşti | 0:1 |  |
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| 5. Round | 15/08/2021 | Rapid Bucureşti | - | FCSB | 1:0 | |
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| 6. Round | 22/08/2021 | FC Botoşani | - | Rapid Bucureşti | 0:2 | ||||
| 7. Round | 28/08/2021 | Rapid Bucureşti | - | CS Universitatea Craiova | 1:2 | ||||
| 8. Round | 10/09/2021 | UTA Arad | - | Rapid Bucureşti | 2:2 | ||||
| 9. Round | 17/09/2021 | Rapid Bucureşti | - | Gaz Metan Mediaş | 1:2 | ||||
| 10. Round | 24/09/2021 | Rapid Bucureşti | - | FC Voluntari | 0:1 | |
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| 11. Round | 02/10/2021 | Sepsi OSK | - | Rapid Bucureşti | 2:2 | ||||
| 13. Round | 23/10/2021 | Dinamo Bucureşti | - | Rapid Bucureşti | 1:1 |  |
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| 25. Round | 08/02/2022 | FC Voluntari | - | Rapid Bucureşti | 0:0 | ||||
| 26. Round | 11/02/2022 | Rapid Bucureşti | - | Sepsi OSK | 1:1 | |
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| 29. Round | 01/03/2022 | FC Universitatea Craiova | - | Rapid Bucureşti | 3:2 |
Romania