| 2. Round | 20/03/2022 | Dinamo Bucureşti | - | Sepsi OSK | 0:0 | ||||
| 3. Round | 04/04/2022 | Sepsi OSK | - | Academica Clinceni | 6:0 |  |
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| 4. Round | 10/04/2022 | FC Botoşani | - | Sepsi OSK | 0:1 | ||||
| 5. Round | 16/04/2022 | Sepsi OSK | - | UTA Arad | 1:0 |  |
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| 6. Round | 23/04/2022 | Rapid Bucureşti | - | Sepsi OSK | 1:0 | ||||
| 8. Round | 08/05/2022 | Sepsi OSK | - | Chindia Târgoviște | 2:1 | |
Romania