| 1. Round | 12/02/2021 | Unión de Santa Fe II | - | Atlético Tucumán II | 2:1 |  |
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| 4. Round | 05/03/2021 | Patronato de Paraná II | - | Unión de Santa Fe II | 0:4 | |
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| 5. Round | 12/03/2021 | Unión de Santa Fe II | - | Gimnasia de La Plata II | 3:1 | ||||
| 6. Round | 19/03/2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 3:1 | |
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| 9. Round | 09/04/2021 | Unión de Santa Fe II | - | Boca Juniors II | 2:3 | ||||
| 10. Round | 16/04/2021 | Talleres de Córdoba II | - | Unión de Santa Fe II | 0:0 | ||||
| 11. Round | 23/04/2021 | Unión de Santa Fe II | - | Independiente II | 1:1 |
Argentina
Switzerland