| 1. Round | 08/02/2008 | San Lorenzo | - | Newell's Old Boys | 0:2 | ||||
| 2. Round | 17/02/2008 | Newell's Old Boys | - | River Plate | 0:0 | ||||
| 3. Round | 22/02/2008 | Estudiantes | - | Newell's Old Boys | 5:2 | ||||
| 4. Round | 02/03/2008 | Newell's Old Boys | - | Racing Club | 1:0 | ||||
| 5. Round | 08/03/2008 | Vélez Sarsfield | - | Newell's Old Boys | 1:0 | ||||
| 6. Round | 16/03/2008 | Newell's Old Boys | - | Arsenal de Sarandí | 4:1 | ||||
| 7. Round | 24/03/2008 | Lanús | - | Newell's Old Boys | 1:1 |  |
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| 8. Round | 30/03/2008 | Newell's Old Boys | - | Tigre | 1:1 | ||||
| 9. Round | 05/04/2008 | Rosario Central | - | Newell's Old Boys | 0:1 | ||||
| 10. Round | 12/04/2008 | Newell's Old Boys | - | Argentinos Juniors | 2:0 | |
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| 11. Round | 19/04/2008 | Boca Juniors | - | Newell's Old Boys | 2:1 | ||||
| 12. Round | 27/04/2008 | Newell's Old Boys | - | Gimnasia de La Plata | 1:0 | ||||
| 13. Round | 03/05/2008 | Independiente | - | Newell's Old Boys | 3:0 | ||||
| 14. Round | 11/05/2008 | Newell's Old Boys | - | Huracán | 0:1 | ||||
| 16. Round | 26/05/2008 | Newell's Old Boys | - | Olimpo de Bahía Blanca | 0:1 |
Argentina