| 1. Round | 27/08/2022 | Real Murcia | - | CD Calahorra | 0:0 | ||||
| 2. Round | 04/09/2022 | CF Intercity | - | Real Murcia | 1:3 |  |
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| 3. Round | 10/09/2022 | Real Sociedad B | - | Real Murcia | 1:2 | ||||
| 4. Round | 17/09/2022 | Real Murcia | - | CD Numancia | 0:0 | ||||
| 5. Round | 24/09/2022 | FC Barcelona B | - | Real Murcia | 2:0 | |
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| 6. Round | 01/10/2022 | Real Murcia | - | SD Logroñés | 4:2 |  |
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| 7. Round | 09/10/2022 | Gimnàstic de Tarragona | - | Real Murcia | 3:2 | ||||
| 8. Round | 16/10/2022 | Real Murcia | - | Real Unión | 0:0 | |
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| 9. Round | 23/10/2022 | Athletic Club B | - | Real Murcia | 0:3 | |
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| 10. Round | 30/10/2022 | Real Murcia | - | CA Osasuna B | 1:4 | ||||
| 11. Round | 06/11/2022 | CF La Nucía | - | Real Murcia | 0:0 | ||||
| 12. Round | 19/11/2022 | Real Murcia | - | UD Logroñés | 1:0 | ||||
| 16. Round | 11/12/2022 | Real Murcia | - | CE Sabadell | 3:1 | ||||
| 19. Round | 14/01/2023 | CD Eldense | - | Real Murcia | 1:0 | ||||
| 20. Round | 21/01/2023 | Real Murcia | - | Athletic Club B | 3:1 |
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