| 1. Round | 06/02/2016 | Rentistas | - | Plaza Colonia | 1:3 |  |
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| 2. Round | 13/02/2016 | Plaza Colonia | - | Liverpool | 1:0 | ||||
| 3. Round | 21/02/2016 | Villa Teresa | - | Plaza Colonia | 1:1 | |
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| 4. Round | 28/02/2016 | Plaza Colonia | - | Nacional | 2:0 | ||||
| 5. Round | 06/03/2016 | Montevideo Wanderers | - | Plaza Colonia | 0:1 | ||||
| 6. Round | 20/03/2016 | River Plate | - | Plaza Colonia | 0:1 | ||||
| 7. Round | 02/04/2016 | Plaza Colonia | - | Juventud de Las Piedras | 1:2 | |
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| 8. Round | 10/04/2016 | CA Cerro | - | Plaza Colonia | 0:0 | ||||
| 9. Round | 23/04/2016 | Plaza Colonia | - | El Tanque Sisley | 2:1 |  |
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| 10. Round | 30/04/2016 | Defensor Sporting | - | Plaza Colonia | 1:1 | ||||
| 11. Round | 07/05/2016 | Plaza Colonia | - | Fénix | 1:0 | ||||
| 12. Round | 15/05/2016 | Sud América | - | Plaza Colonia | 0:2 | ||||
| 13. Round | 21/05/2016 | Plaza Colonia | - | Racing | 2:2 | ||||
| 14. Round | 29/05/2016 | Peñarol | - | Plaza Colonia | 1:2 | |
Uruguay