| 1. Round | 16/10/2021 | Espérance Zarzis | - | Olympique Béja | 0:2 | ||||
| 2. Round | 23/10/2021 | CS Chebba | - | Espérance Zarzis | 0:0 | ||||
| 3. Round | 30/10/2021 | Espérance Zarzis | - | AS Rejiche | 0:0 | ||||
| 4. Round | 04/11/2021 | Étoile du Sahel | - | Espérance Zarzis | 1:1 |  |
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| 5. Round | 07/11/2021 | Espérance Zarzis | - | AS Soliman | 0:0 | ||||
| 6. Round | 18/11/2021 | Club Africain | - | Espérance Zarzis | 1:0 | ||||
| 7. Round | 21/11/2021 | Espérance Zarzis | - | US Monastir | 0:1 | ||||
| 8. Round | 20/02/2022 | Olympique Béja | - | Espérance Zarzis | 0:1 | ||||
| 9. Round | 26/02/2022 | Espérance Zarzis | - | CS Chebba | 2:1 | ||||
| 10. Round | 09/03/2022 | AS Rejiche | - | Espérance Zarzis | 1:0 | |
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| 11. Round | 16/03/2022 | Espérance Zarzis | - | Étoile du Sahel | 0:3 | |
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| 13. Round | 10/04/2022 | Espérance Zarzis | - | Club Africain | 0:1 | ||||
| 14. Round | 13/04/2022 | US Monastir | - | Espérance Zarzis | 0:1 |
Tunisia