| 16. Round | 18/07/2021 | FK Vitebsk | - | Neman Grodno | 2:0 |  |
|||
| 17. Round | 24/07/2021 | Neman Grodno | - | FK Slutsk | 1:0 | ||||
| 18. Round | 02/08/2021 | Dinamo Brest | - | Neman Grodno | 1:3 | ||||
| 19. Round | 15/08/2021 | Neman Grodno | - | FK Gomel | 1:0 | ||||
| 20. Round | 22/08/2021 | FK Minsk | - | Neman Grodno | 0:4 | ||||
| 21. Round | 29/08/2021 | Neman Grodno | - | Energetik-BGU Minsk | 3:0 | ||||
| 22. Round | 11/09/2021 | FK Isloch Minsk | - | Neman Grodno | 2:0 | ||||
| 23. Round | 19/09/2021 | Neman Grodno | - | FK Smorgon | 5:0 | ||||
| 24. Round | 26/09/2021 | Shakhter Soligorsk | - | Neman Grodno | 1:0 | ||||
| 25. Round | 01/10/2021 | Neman Grodno | - | Rukh Brest | 0:1 | ||||
| 27. Round | 22/10/2021 | Neman Grodno | - | BATE Borisov | 0:2 | ||||
| 28. Round | 07/11/2021 | FK Slaviya Mozyr | - | Neman Grodno | 1:1 | ||||
| 30. Round | 28/11/2021 | Neman Grodno | - | Torpedo-BelAZ Zhodino | 3:1 |
Belarus