| 16. Round | 18/07/2021 | FK Slaviya Mozyr | - | FK Isloch Minsk | 1:1 |  |
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| 17. Round | 25/07/2021 | FK Smorgon | - | FK Isloch Minsk | 1:2 | ||||
| 18. Round | 02/08/2021 | FK Isloch Minsk | - | Shakhter Soligorsk | 0:1 | |
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| 19. Round | 13/08/2021 | Rukh Brest | - | FK Isloch Minsk | 7:1 | ||||
| 21. Round | 28/08/2021 | BATE Borisov | - | FK Isloch Minsk | 2:2 | ||||
| 22. Round | 11/09/2021 | FK Isloch Minsk | - | Neman Grodno | 2:0 | |
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| 23. Round | 19/09/2021 | Dinamo Minsk | - | FK Isloch Minsk | 2:1 | ||||
| 24. Round | 25/09/2021 | FK Isloch Minsk | - | Torpedo-BelAZ Zhodino | 0:0 | ||||
| 25. Round | 02/10/2021 | FK Vitebsk | - | FK Isloch Minsk | 0:4 |  |
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| 26. Round | 16/10/2021 | FK Isloch Minsk | - | FK Slutsk | 2:0 | ||||
| 27. Round | 23/10/2021 | Dinamo Brest | - | FK Isloch Minsk | 1:0 | ||||
| 28. Round | 07/11/2021 | FK Isloch Minsk | - | FK Gomel | 1:2 | ||||
| 29. Round | 20/11/2021 | FK Minsk | - | FK Isloch Minsk | 1:0 | |
Belarus