| 1. Round | 25/02/2024 | St. Louis City SC | - | Real Salt Lake | 1:1 | ||||
| 5. Round | 24/03/2024 | St. Louis City SC | - | D.C. United | 2:2 |  |
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| 6. Round | 31/03/2024 | Real Salt Lake | - | St. Louis City SC | 3:1 | ||||
| 7. Round | 07/04/2024 | St. Louis City SC | - | FC Dallas | 0:0 | ||||
| 13. Round | 16/05/2024 | St. Louis City SC | - | Los Angeles FC | 0:2 | |
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| 14. Round | 19/05/2024 | FC Cincinnati | - | St. Louis City SC | 3:1 | ||||
| 15. Round | 26/05/2024 | St. Louis City SC | - | Seattle Sounders | 1:2 | |
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| 18. Round | 16/06/2024 | FC Dallas | - | St. Louis City SC | 2:0 | ||||
| 19. Round | 20/06/2024 | St. Louis City SC | - | Colorado Rapids | 0:3 | ||||
| 20. Round | 23/06/2024 | St. Louis City SC | - | Atlanta United FC | 1:1 | ||||
| 21. Round | 30/06/2024 | Vancouver Whitecaps | - | St. Louis City SC | 4:3 |  |
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| 22. Round | 04/07/2024 | St. Louis City SC | - | San Jose Earthquakes | 2:0 | ||||
| 23. Round | 08/07/2024 | Colorado Rapids | - | St. Louis City SC | 4:1 | ||||
| 24. Round | 14/07/2024 | St. Louis City SC | - | Vancouver Whitecaps | 1:4 | |
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| 25. Round | 18/07/2024 | Seattle Sounders | - | St. Louis City SC | 2:0 | ||||
| 26. Round | 21/07/2024 | Sporting Kansas City | - | St. Louis City SC | 1:1 |
South Africa