| 4. Round | 18/09/2021 | Kaizer Chiefs | - | Royal AM | 1:4 | ||||
| 6. Round | 02/10/2021 | AmaZulu FC | - | Kaizer Chiefs | 1:1 | ||||
| 7. Round | 16/10/2021 | Kaizer Chiefs | - | Chippa United | 4:0 | ||||
| 8. Round | 24/10/2021 | SuperSport United | - | Kaizer Chiefs | 1:2 | ||||
| 9. Round | 02/11/2021 | Kaizer Chiefs | - | Stellenbosch FC | 0:1 | ||||
| 10. Round | 06/11/2021 | Kaizer Chiefs | - | Orlando Pirates | 2:1 | ||||
| 11. Round | 21/11/2021 | Maritzburg United | - | Kaizer Chiefs | 0:1 |  |
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| 19. Round | 24/11/2021 | Kaizer Chiefs | - | AmaZulu FC | 1:1 | ||||
| 15. Round | 12/12/2021 | Kaizer Chiefs | - | Sekhukhune United | 2:0 | ||||
| 17. Round | 22/12/2021 | Kaizer Chiefs | - | Maritzburg United | 2:0 | ||||
| 21. Round | 05/03/2022 | Orlando Pirates | - | Kaizer Chiefs | 1:2 | ||||
| 22. Round | 19/03/2022 | Kaizer Chiefs | - | Golden Arrows | 0:1 | ||||
| 24. Round | 05/04/2022 | Kaizer Chiefs | - | TS Galaxy | 0:0 | ||||
| 26. Round | 23/04/2022 | Stellenbosch FC | - | Kaizer Chiefs | 1:0 | ||||
| 14. Round | 27/04/2022 | Golden Arrows | - | Kaizer Chiefs | 2:1 | ||||
| 30. Round | 21/05/2022 | Kaizer Chiefs | - | Moroka Swallows | 2:2 |  |
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South Africa