| 1. Round | 25/07/2021 | Club Brugge KV | - | KAS Eupen | 2:2 | ||||
| 2. Round | 01/08/2021 | Union Saint-Gilloise | - | Club Brugge KV | 0:1 | ||||
| 3. Round | 06/08/2021 | Club Brugge KV | - | Cercle Brugge | 1:1 |  |
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| 4. Round | 15/08/2021 | SV Zulte Waregem | - | Club Brugge KV | 0:4 | ||||
| 6. Round | 29/08/2021 | KAA Gent | - | Club Brugge KV | 6:1 | |
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| 7. Round | 10/09/2021 | Club Brugge KV | - | KV Oostende | 3:0 | ||||
| 9. Round | 24/09/2021 | Club Brugge KV | - | Oud-Heverlee Leuven | 1:1 | ||||
| 11. Round | 15/10/2021 | Club Brugge KV | - | KV Kortrijk | 2:0 | ||||
| 12. Round | 24/10/2021 | Royal Antwerp FC | - | Club Brugge KV | 1:1 | ||||
| 15. Round | 19/11/2021 | KV Mechelen | - | Club Brugge KV | 2:1 | ||||
| 17. Round | 04/12/2021 | Club Brugge KV | - | RFC Seraing | 3:2 | ||||
| 19. Round | 15/12/2021 | Oud-Heverlee Leuven | - | Club Brugge KV | 1:4 | ||||
| 20. Round | 19/12/2021 | Club Brugge KV | - | RSC Anderlecht | 2:2 | ||||
| 21. Round | 26/12/2021 | Cercle Brugge | - | Club Brugge KV | 2:0 |
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