| 1. Round | 30/08/2021 | Hapoel Nof HaGalil | - | Hapoel Jerusalem | 0:0 | ||||
| 4. Round | 25/09/2021 | Hapoel Jerusalem | - | Bnei Sachnin FC | 0:0 | ||||
| 5. Round | 03/10/2021 | Maccabi Tel Aviv | - | Hapoel Jerusalem | 1:0 | ||||
| 6. Round | 16/10/2021 | Hapoel Jerusalem | - | Maccabi Haifa | 1:4 |  |
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| 7. Round | 23/10/2021 | Hapoel Be'er Sheva | - | Hapoel Jerusalem | 3:1 | |
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| 8. Round | 30/10/2021 | Hapoel Jerusalem | - | Maccabi Petach-Tikva | 1:0 | ||||
| 9. Round | 06/11/2021 | Hapoel Jerusalem | - | Maccabi Netanya | 2:1 | ||||
| 10. Round | 27/11/2021 | FC Ashdod | - | Hapoel Jerusalem | 1:0 | ||||
| 14. Round | 21/12/2021 | Hapoel Jerusalem | - | Hapoel Nof HaGalil | 3:1 | ||||
| 18. Round | 15/01/2022 | Hapoel Jerusalem | - | Maccabi Tel Aviv | 1:3 | ||||
| 19. Round | 22/01/2022 | Maccabi Haifa | - | Hapoel Jerusalem | 1:1 | ||||
| 20. Round | 29/01/2022 | Hapoel Jerusalem | - | Hapoel Be'er Sheva | 0:1 | ||||
| 21. Round | 05/02/2022 | Maccabi Petach-Tikva | - | Hapoel Jerusalem | 3:1 | |
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| 26. Round | 13/03/2022 | Hapoel Haifa | - | Hapoel Jerusalem | 1:2 |
Israel