| 7. Round | 02/09/2021 | FK Ural 2 | - | Irtysh Omsk | 1:1 | ||||
| 8. Round | 05/09/2021 | FK Chelyabinsk | - | Irtysh Omsk | 4:1 | ||||
| 13. Round | 13/10/2021 | Irtysh Omsk | - | FK Novosibirsk | 3:1 |  |
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| 15. Round | 17/10/2021 | Dinamo Barnaul | - | Irtysh Omsk | 1:1 | ||||
| 16. Round | 20/10/2021 | FK Novosibirsk | - | Irtysh Omsk | 2:0 | ||||
| 20. Round | 12/11/2021 | Irtysh Omsk | - | Lada Tolyatti | 1:1 | ||||
| 22. Round | 10/04/2022 | Spartak Tuymazy | - | Irtysh Omsk | 0:6 | ||||
| 21. Round | 13/04/2022 | Torpedo Miass | - | Irtysh Omsk | 2:0 | ||||
| 23. Round | 21/04/2022 | Irtysh Omsk | - | FK Chelyabinsk | 1:2 | ||||
| 24. Round | 24/04/2022 | Irtysh Omsk | - | FK Ural 2 | 2:2 | ||||
| 26. Round | 08/05/2022 | Zvezda Perm | - | Irtysh Omsk | 2:1 | ||||
| 27. Round | 18/05/2022 | Irtysh Omsk | - | FK Orenburg 2 | 1:1 | ||||
| 28. Round | 21/05/2022 | Irtysh Omsk | - | Nosta Novotroitsk | 4:0 | |
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| 29. Round | 01/06/2022 | FK Amkar Perm | - | Irtysh Omsk | 2:0 | ||||
| 30. Round | 04/06/2022 | Zenit Izhevsk | - | Irtysh Omsk | 0:3 | |
Russia
Georgia