| 1. Round | 15/08/2021 | Excelsior Virton | - | KVC Westerlo | 0:2 | ||||
| 2. Round | 20/08/2021 | KVC Westerlo | - | RWD Molenbeek | 0:0 | ||||
| 3. Round | 28/08/2021 | KVC Westerlo | - | Lierse Kempenzonen | 3:2 | ||||
| 4. Round | 12/09/2021 | Waasland-Beveren | - | KVC Westerlo | 0:2 | ||||
| 5. Round | 19/09/2021 | KVC Westerlo | - | KMSK Deinze | 2:2 | ||||
| 10. Round | 31/10/2021 | KMSK Deinze | - | KVC Westerlo | 2:1 | ||||
| 19. Round | 06/02/2022 | KVC Westerlo | - | Lommel SK | 3:0 | ||||
| 23. Round | 04/03/2022 | KMSK Deinze | - | KVC Westerlo | 1:2 |  |
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| 24. Round | 11/03/2022 | Excelsior Virton | - | KVC Westerlo | 1:0 | ||||
| 21. Round | 16/03/2022 | Lierse Kempenzonen | - | KVC Westerlo | 1:0 |  |
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| 25. Round | 20/03/2022 | KVC Westerlo | - | Lierse Kempenzonen | 2:0 | ||||
| 26. Round | 02/04/2022 | Lommel SK | - | KVC Westerlo | 2:1 | ||||
| 27. Round | 08/04/2022 | Royal Excel Mouscron | - | KVC Westerlo | 2:6 | ||||
| 28. Round | 16/04/2022 | KVC Westerlo | - | RWD Molenbeek | 2:2 |
Senegal