| 1. Round | 22/01/2022 | Diriangén FC | - | UNAN Managua | 4:0 | ||||
| 3. Round | 09/02/2022 | UNAN Managua | - | ART Municipal Jalapa | 0:0 | ||||
| 5. Round | 20/02/2022 | UNAN Managua | - | CD Walter Ferretti | 2:2 | ||||
| 8. Round | 06/03/2022 | UNAN Managua | - | Club Deportivo Ocotal | 2:1 | ||||
| 10. Round | 13/03/2022 | UNAN Managua | - | Diriangén FC | 0:3 | ||||
| 13. Round | 07/04/2022 | UNAN Managua | - | Real Madriz | 3:1 | ||||
| 14. Round | 11/04/2022 | CD Walter Ferretti | - | UNAN Managua | 4:1 | ||||
| 16. Round | 25/04/2022 | UNAN Managua | - | Managua FC | 0:1 | ||||
| 17. Round | 28/04/2022 | Club Deportivo Ocotal | - | UNAN Managua | 0:0 | ||||
| 18. Round | 01/05/2022 | Juventus Managua | - | UNAN Managua | 1:3 |
Nicaragua