| 1. Round | 28/08/2021 | Hapoel Tel Aviv | - | FC Ashdod | 2:1 | ||||
| 2. Round | 12/09/2021 | FC Ashdod | - | Hapoel Haifa | 1:3 |  |
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| 3. Round | 18/09/2021 | Hapoel Nof HaGalil | - | FC Ashdod | 2:0 | ||||
| 6. Round | 16/10/2021 | FC Ashdod | - | Bnei Sachnin FC | 0:1 | ||||
| 14. Round | 21/12/2021 | FC Ashdod | - | Hapoel Tel Aviv | 1:4 | ||||
| 16. Round | 02/01/2022 | FC Ashdod | - | Hapoel Nof HaGalil | 3:0 | ||||
| 17. Round | 09/01/2022 | Beitar Jerusalem | - | FC Ashdod | 0:2 | ||||
| 18. Round | 16/01/2022 | Hapoel Hadera | - | FC Ashdod | 2:1 | ||||
| 19. Round | 23/01/2022 | Bnei Sachnin FC | - | FC Ashdod | 0:1 | ||||
| 20. Round | 29/01/2022 | FC Ashdod | - | Maccabi Tel Aviv | 1:3 | ||||
| 23. Round | 19/02/2022 | Hapoel Jerusalem | - | FC Ashdod | 2:0 | ||||
| 24. Round | 26/02/2022 | FC Ashdod | - | Maccabi Netanya | 1:3 | ||||
| 25. Round | 06/03/2022 | FC Ashdod | - | Maccabi Petach-Tikva | 3:4 | ||||
| 26. Round | 12/03/2022 | Ironi Kiryat Shmona | - | FC Ashdod | 2:0 |
Israel