| 16. Round | 04/12/1999 | KSK Beveren | - | Sporting Lokeren | 2:1 | ||||
| 17. Round | 11/12/1999 | Sporting Lokeren | - | Lierse SK (old) | 5:1 | ||||
| 19. Round | 16/01/2000 | Club Brugge KV | - | Sporting Lokeren | 6:1 | ||||
| 20. Round | 22/01/2000 | Sporting Lokeren | - | Sint-Truidense VV | 3:0 | ||||
| 21. Round | 29/01/2000 | Verbroedering Geel | - | Sporting Lokeren | 3:0 | ||||
| 24. Round | 19/02/2000 | RSC Anderlecht | - | Sporting Lokeren | 5:0 | ||||
| 28. Round | 26/03/2000 | KAA Gent | - | Sporting Lokeren | 1:1 | ||||
| 30. Round | 07/04/2000 | Standard Liège | - | Sporting Lokeren | 1:2 | ||||
| 31. Round | 15/04/2000 | Sporting Lokeren | - | RSC Charleroi | 1:1 |
Croatia