| 16. Round | 17/07/2021 | FK Gomel | - | Rukh Brest | 0:0 | ||||
| 17. Round | 23/07/2021 | Rukh Brest | - | FK Minsk | 1:0 |  |
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| 18. Round | 30/07/2021 | Energetik-BGU Minsk | - | Rukh Brest | 0:2 | |
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| 19. Round | 13/08/2021 | Rukh Brest | - | FK Isloch Minsk | 7:1 | ||||
| 20. Round | 21/08/2021 | FK Smorgon | - | Rukh Brest | 1:1 |  |
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| 21. Round | 27/08/2021 | Rukh Brest | - | Shakhter Soligorsk | 1:0 | ||||
| 22. Round | 12/09/2021 | FK Slaviya Mozyr | - | Rukh Brest | 1:1 | ||||
| 24. Round | 25/09/2021 | Rukh Brest | - | BATE Borisov | 2:2 | ||||
| 25. Round | 01/10/2021 | Neman Grodno | - | Rukh Brest | 0:1 | ||||
| 26. Round | 17/10/2021 | Rukh Brest | - | Dinamo Minsk | 1:3 | |
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| 27. Round | 24/10/2021 | Torpedo-BelAZ Zhodino | - | Rukh Brest | 3:3 | |
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| 28. Round | 05/11/2021 | Rukh Brest | - | FK Vitebsk | 2:0 | ||||
| 29. Round | 20/11/2021 | FK Slutsk | - | Rukh Brest | 3:0 | ||||
| 30. Round | 28/11/2021 | Rukh Brest | - | Dinamo Brest | 3:2 | |
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Ukraine