| 1. Round | 09/07/2010 | FK Illichivets | - | Metalurh Donetsk | 1:1 | ||||
| 2. Round | 17/07/2010 | Vorskla Poltava | - | FK Illichivets | 1:3 |  |
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| 3. Round | 24/07/2010 | FK Illichivets | - | Dnipro Dnipropetrovsk | 1:5 | ||||
| 4. Round | 31/07/2010 | FK Krivbas (old) | - | FK Illichivets | 1:0 | ||||
| 5. Round | 06/08/2010 | FK Illichivets | - | Metalurg Zaporizhya | 0:0 | ||||
| 8. Round | 29/08/2010 | Shakhtar Donetsk | - | FK Illichivets | 1:0 | ||||
| 11. Round | 25/09/2010 | FK Illichivets | - | PFK Sevastopol | 4:2 |  |
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| 12. Round | 02/10/2010 | FK Illichivets | - | FK Obolon | 1:0 | ||||
| 13. Round | 15/10/2010 | Tavriya Simferopol (1958-2014) | - | FK Illichivets | 2:2 | |
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| 14. Round | 24/10/2010 | FK Illichivets | - | Metalist Kharkiv | 1:4 | ||||
| 15. Round | 31/10/2010 | Dinamo Kiev | - | FK Illichivets | 9:0 | ||||
| 16. Round | 07/11/2010 | Metalurh Donetsk | - | FK Illichivets | 0:3 | |
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| 17. Round | 13/11/2010 | FK Illichivets | - | Vorskla Poltava | 2:6 | ||||
| 18. Round | 21/11/2010 | Dnipro Dnipropetrovsk | - | FK Illichivets | 2:0 | |
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| 23. Round | 01/04/2011 | FK Illichivets | - | Shakhtar Donetsk | 1:3 | ||||
| 27. Round | 30/04/2011 | FK Obolon | - | FK Illichivets | 2:0 |
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