| 1. Round | 22/08/2020 | FK Oleksandriya | - | FK Mariupol | 4:1 |  |
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| 2. Round | 13/09/2020 | Zorya Lugansk | - | FK Mariupol | 0:1 | ||||
| 3. Round | 18/09/2020 | SK Dnipro-1 | - | FK Mariupol | 1:2 | ||||
| 4. Round | 26/09/2020 | Vorskla Poltava | - | FK Mariupol | 0:0 | |
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| 5. Round | 04/10/2020 | Kolos Kovalivka | - | FK Mariupol | 1:0 | ||||
| 6. Round | 17/10/2020 | FC Mynai | - | FK Mariupol | 0:1 | |
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| 7. Round | 25/10/2020 | Inhulets Petrove | - | FK Mariupol | 1:1 | |
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| 9. Round | 07/11/2020 | Olimpik Donetsk | - | FK Mariupol | 3:3 | ||||
| 14. Round | 14/02/2021 | FK Mariupol | - | FK Oleksandriya | 0:1 | |
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| 15. Round | 20/02/2021 | FK Mariupol | - | Zorya Lugansk | 0:1 | ||||
| 16. Round | 27/02/2021 | FK Mariupol | - | SK Dnipro-1 | 2:2 | |
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| 17. Round | 06/03/2021 | FK Mariupol | - | Vorskla Poltava | 0:1 |  |
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| 19. Round | 20/03/2021 | FK Mariupol | - | FC Mynai | 0:0 | ||||
| 20. Round | 03/04/2021 | FK Mariupol | - | Inhulets Petrove | 4:3 | ||||
| 21. Round | 10/04/2021 | FK Mariupol | - | Shakhtar Donetsk | 0:3 | ||||
| 22. Round | 18/04/2021 | FK Mariupol | - | Olimpik Donetsk | 1:1 | ||||
| 23. Round | 23/04/2021 | FK Mariupol | - | Rukh Lviv | 0:3 | |
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| 24. Round | 02/05/2021 | FK Mariupol | - | FK Lviv | 1:2 | |
Ukraine