| 3. Round | 08/08/2021 | Vorskla Poltava | - | FK Lviv | 4:1 |  |
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| 4. Round | 15/08/2021 | FK Lviv | - | FK Oleksandriya | 1:1 | ||||
| 5. Round | 23/08/2021 | FK Lviv | - | Inhulets Petrove | 1:2 |  |
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| 6. Round | 29/08/2021 | Rukh Lviv | - | FK Lviv | 1:0 | ||||
| 7. Round | 13/09/2021 | NK Veres | - | FK Lviv | 1:0 | |
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| 8. Round | 19/09/2021 | FK Lviv | - | Metalist 1925 Kharkiv | 0:0 | |
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| 9. Round | 26/09/2021 | FC Mynai | - | FK Lviv | 1:2 | |
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| 11. Round | 16/10/2021 | FK Lviv | - | Dinamo Kiev | 1:4 | ||||
| 12. Round | 23/10/2021 | Chernomorets Odessa | - | FK Lviv | 1:1 | ||||
| 13. Round | 31/10/2021 | Kolos Kovalivka | - | FK Lviv | 0:1 | |
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| 14. Round | 07/11/2021 | FK Lviv | - | Desna Chernigov | 0:2 | ||||
| 15. Round | 20/11/2021 | FK Lviv | - | Zorya Lugansk | 2:1 | |
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| 16. Round | 26/11/2021 | FK Mariupol | - | FK Lviv | 0:1 | |
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| 17. Round | 03/12/2021 | Shakhtar Donetsk | - | FK Lviv | 6:1 | |
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| 18. Round | 11/12/2021 | FK Lviv | - | Vorskla Poltava | 1:1 | |
Ukraine