| 1. Round | 09/07/2010 | FK Illichivets | - | Metalurh Donetsk | 1:1 | ||||
| 2. Round | 16/07/2010 | Metalurh Donetsk | - | FK Obolon | 3:0 |  |
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| 3. Round | 24/07/2010 | Tavriya Simferopol (1958-2014) | - | Metalurh Donetsk | 2:1 | ||||
| 6. Round | 15/08/2010 | PFK Sevastopol | - | Metalurh Donetsk | 0:1 | ||||
| 7. Round | 21/08/2010 | Metalurh Donetsk | - | Vorskla Poltava | 2:0 | ||||
| 8. Round | 30/08/2010 | Dnipro Dnipropetrovsk | - | Metalurh Donetsk | 1:2 | ||||
| 9. Round | 11/09/2010 | Metalurh Donetsk | - | FK Krivbas (old) | 2:2 | ||||
| 11. Round | 26/09/2010 | Metalurh Donetsk | - | Zorya Lugansk | 1:1 | ||||
| 12. Round | 02/10/2010 | Arsenal Kiev | - | Metalurh Donetsk | 3:1 | ||||
| 13. Round | 15/10/2010 | Metalurh Donetsk | - | Shakhtar Donetsk | 0:2 | ||||
| 14. Round | 24/10/2010 | Karpaty Lviv | - | Metalurh Donetsk | 2:1 |  |
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| 15. Round | 31/10/2010 | Metalurh Donetsk | - | Volyn Lutsk | 0:2 | ||||
| 16. Round | 07/11/2010 | Metalurh Donetsk | - | FK Illichivets | 0:3 | ||||
| 17. Round | 12/11/2010 | FK Obolon | - | Metalurh Donetsk | 1:1 | ||||
| 18. Round | 21/11/2010 | Metalurh Donetsk | - | Tavriya Simferopol (1958-2014) | 2:1 | |
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| 21. Round | 12/03/2011 | Metalurh Donetsk | - | PFK Sevastopol | 1:0 | |
Ukraine