| 8. Round | 02/09/2024 | Atlético Junior | - | Santa Fe | 1:1 | ||||
| 11. Round | 22/09/2024 | Fortaleza FC | - | Santa Fe | 1:3 |  |
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| 10. Round | 27/09/2024 | Santa Fe | - | Alianza FC | 2:0 | ||||
| 12. Round | 30/09/2024 | Deportes Tolima | - | Santa Fe | 0:0 | ||||
| 9. Round | 11/10/2024 | Santa Fe | - | Boyacá Chicó | 3:1 | ||||
| 14. Round | 14/10/2024 | Patriotas FC | - | Santa Fe | 1:2 | |
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| 5. Round | 19/10/2024 | Santa Fe | - | Independiente Medellín | 1:1 | |
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| 15. Round | 27/10/2024 | Santa Fe | - | Millonarios | 0:1 | ||||
| 16. Round | 05/11/2024 | Atlético Nacional | - | Santa Fe | 1:1 | ||||
| 17. Round | 09/11/2024 | Santa Fe | - | Once Caldas | 2:1 | ||||
| 19. Round | 15/11/2024 | Santa Fe | - | Jaguares de Córdoba | 3:0 | |
Colombia