| 2. Round | 01/02/2025 | Santa Fe | - | Deportes Tolima | 0:0 | ||||
| 7. Round | 28/02/2025 | Envigado FC | - | Santa Fe | 1:7 | ||||
| 8. Round | 09/03/2025 | Santa Fe | - | Fortaleza FC | 2:0 | ||||
| 9. Round | 16/03/2025 | Once Caldas | - | Santa Fe | 0:1 | ||||
| 6. Round | 19/03/2025 | Santa Fe | - | Atlético Bucaramanga | 1:1 | ||||
| 10. Round | 23/03/2025 | Santa Fe | - | Millonarios | 3:2 | ||||
| 11. Round | 30/03/2025 | Unión Magdalena | - | Santa Fe | 0:1 |  |
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| 12. Round | 05/04/2025 | Santa Fe | - | Deportivo Pasto | 1:1 | ||||
| 13. Round | 11/04/2025 | La Equidad | - | Santa Fe | 2:1 | ||||
| 14. Round | 15/04/2025 | Santa Fe | - | Independiente Medellín | 1:2 |  |
Colombia