| 1. Round | 26/10/2021 | Al Mokawloon | - | El Sharkia Lel Dokhan | 1:0 | ||||
| 2. Round | 30/10/2021 | ENPPI | - | Al Mokawloon | 3:2 | ||||
| 3. Round | 04/11/2021 | Al Mokawloon | - | Tala'ea El Gaish SC | 1:1 |  |
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| 4. Round | 19/11/2021 | Al Ahly SC | - | Al Mokawloon | 1:0 | ||||
| 5. Round | 23/11/2021 | Al Mokawloon | - | Ismaily | 1:1 | ||||
| 7. Round | 21/12/2021 | Al Mokawloon | - | Zamalek | 1:2 | |
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| 12. Round | 04/03/2022 | Al Mokawloon | - | Pyramids FC | 0:2 | ||||
| 23. Round | 28/06/2022 | Al Mokawloon | - | National Bank SC | 1:1 | ||||
| 24. Round | 12/07/2022 | Zamalek | - | Al Mokawloon | 1:0 | ||||
| 25. Round | 17/07/2022 | Al Mokawloon | - | Ceramica Cleopatra | 0:1 | |
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| 26. Round | 22/07/2022 | Al Mokawloon | - | Ghazl Al Mehalla | 1:0 | ||||
| 28. Round | 02/08/2022 | Al Mokawloon | - | Future FC | 0:1 |
Egypt