| 1. Round | 10/07/2022 | Millonarios | - | Deportivo Pasto | 1:1 | ||||
| 2. Round | 13/07/2022 | Millonarios | - | Atlético Bucaramanga | 0:0 | ||||
| 3. Round | 17/07/2022 | Atlético Nacional | - | Millonarios | 1:2 | ||||
| 8. Round | 21/08/2022 | Millonarios | - | Jaguares de Córdoba | 2:0 | ||||
| 9. Round | 28/08/2022 | Cortuluá | - | Millonarios | 1:4 | ||||
| 10. Round | 04/09/2022 | Millonarios | - | Santa Fe | 2:0 | ||||
| 11. Round | 11/09/2022 | Once Caldas | - | Millonarios | 2:1 | ||||
| 13. Round | 22/09/2022 | Atlético Junior | - | Millonarios | 0:1 | ||||
| 14. Round | 24/09/2022 | Millonarios | - | América de Cali | 2:2 | ||||
| 15. Round | 02/10/2022 | La Equidad | - | Millonarios | 1:0 | ||||
| 17. Round | 06/10/2022 | Santa Fe | - | Millonarios | 3:2 | ||||
| 18. Round | 17/10/2022 | Millonarios | - | Patriotas FC | 0:0 | ||||
| 16. Round | 20/10/2022 | Millonarios | - | Deportivo Pereira | 0:1 | ||||
| 19. Round | 23/10/2022 | Deportes Tolima | - | Millonarios | 1:0 | ||||
| 12. Round | 27/10/2022 | Millonarios | - | Independiente Medellín | 1:2 |  |
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| 20. Round | 30/10/2022 | Alianza Petrolera | - | Millonarios | 2:4 |
Colombia