| 1. Round | 17/10/2021 | US Monastir | - | CS Chebba | 2:0 |  |
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| 2. Round | 24/10/2021 | AS Rejiche | - | US Monastir | 0:1 | ||||
| 3. Round | 31/10/2021 | US Monastir | - | Étoile du Sahel | 1:0 | ||||
| 4. Round | 04/11/2021 | AS Soliman | - | US Monastir | 0:0 | ||||
| 5. Round | 07/11/2021 | US Monastir | - | Club Africain | 0:0 | ||||
| 6. Round | 18/11/2021 | US Monastir | - | Olympique Béja | 2:1 | ||||
| 7. Round | 21/11/2021 | Espérance Zarzis | - | US Monastir | 0:1 | ||||
| 8. Round | 19/02/2022 | CS Chebba | - | US Monastir | 0:0 | ||||
| 9. Round | 27/02/2022 | US Monastir | - | AS Rejiche | 0:1 | ||||
| 10. Round | 09/03/2022 | Étoile du Sahel | - | US Monastir | 0:0 | |
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| 11. Round | 13/03/2022 | US Monastir | - | AS Soliman | 1:0 | ||||
| 12. Round | 06/04/2022 | Club Africain | - | US Monastir | 2:0 |
Tunisia