| Group B | 25/08/2011 | Isidro Metapán | - | Santos Laguna | 2:0 | ||||
| Group B | 14/09/2011 | Real España | - | Isidro Metapán | 1:2 |  |
|||
| Group B | 23/09/2011 | Santos Laguna | - | Isidro Metapán | 6:0 | ||||
| Group B | 29/09/2011 | Isidro Metapán | - | Colorado Rapids | 1:3 | |
|||
| Quarter-finals | 09/03/2012 | Isidro Metapán | - | Pumas UNAM | 2:1 | ||||
| Quarter-finals | 16/03/2012 | Pumas UNAM | - | Isidro Metapán | 8:0 |
El Salvador