| 2. Round | 12/09/2021 | Doxa Katokopias | - | Anorthosis Famagusta | 2:0 |  |
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| 3. Round | 20/09/2021 | Anorthosis Famagusta | - | Ethnikos Achna | 2:1 | ||||
| 4. Round | 25/09/2021 | Aris Limassol | - | Anorthosis Famagusta | 3:2 | ||||
| 6. Round | 17/10/2021 | AEL Limassol | - | Anorthosis Famagusta | 2:1 | ||||
| 8. Round | 29/10/2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 | ||||
| 10. Round | 20/11/2021 | Olympiakos Nikosia | - | Anorthosis Famagusta | 3:2 | ||||
| 11. Round | 29/11/2021 | Anorthosis Famagusta | - | Apollon Limassol | 1:1 | ||||
| 12. Round | 04/12/2021 | Anorthosis Famagusta | - | PAEEK | 2:3 | ||||
| 1. Round | 22/12/2021 | PAEEK | - | Anorthosis Famagusta | 0:2 | ||||
| 16. Round | 17/02/2022 | APOEL Nikosia | - | Anorthosis Famagusta | 0:2 | ||||
| 22. Round | 26/02/2022 | Apollon Limassol | - | Anorthosis Famagusta | 2:2 |
Cyprus