| 1. Round | 28/08/2021 | ASJ Soyaux [Women] | - | GPSO 92 Issy [Women] | 2:0 |  |
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| 2. Round | 04/09/2021 | Girondins Bordeaux [Women] | - | ASJ Soyaux [Women] | 6:0 | ||||
| 3. Round | 12/09/2021 | ASJ Soyaux [Women] | - | Paris Saint-Germain [Women] | 0:2 | ||||
| 4. Round | 25/09/2021 | FC Fleury 91 [Women] | - | ASJ Soyaux [Women] | 1:0 | ||||
| 5. Round | 02/10/2021 | ASJ Soyaux [Women] | - | Dijon FCO [Women] | 1:2 | ||||
| 6. Round | 16/10/2021 | Paris FC [Women] | - | ASJ Soyaux [Women] | 4:0 | ||||
| 7. Round | 31/10/2021 | ASJ Soyaux [Women] | - | Olympique Lyonnais [Women] | 1:6 | ||||
| 8. Round | 13/11/2021 | EA Guingamp [Women] | - | ASJ Soyaux [Women] | 2:2 | ||||
| 9. Round | 20/11/2021 | ASJ Soyaux [Women] | - | AS Saint-Étienne [Women] | 2:1 | ||||
| 10. Round | 04/12/2021 | Stade de Reims [Women] | - | ASJ Soyaux [Women] | 3:1 | ||||
| 11. Round | 12/12/2021 | ASJ Soyaux [Women] | - | Montpellier HSC [Women] | 0:1 |
Switzerland