| 6. Round | 19/09/2021 | Clermont Foot 63 | - | Stade Brestois 29 | 1:1 | ||||
| 7. Round | 22/09/2021 | Stade Rennais | - | Clermont Foot 63 | 6:0 | ||||
| 12. Round | 31/10/2021 | Clermont Foot 63 | - | Olympique Marseille | 0:1 | ||||
| 14. Round | 21/11/2021 | Clermont Foot 63 | - | OGC Nice | 1:2 | ||||
| 21. Round | 16/01/2022 | AS Monaco | - | Clermont Foot 63 | 4:0 | ||||
| 31. Round | 09/04/2022 | Clermont Foot 63 | - | Paris Saint-Germain | 1:6 | ||||
| 36. Round | 08/05/2022 | Clermont Foot 63 | - | Montpellier HSC | 2:1 | ||||
| 37. Round | 14/05/2022 | RC Strasbourg | - | Clermont Foot 63 | 1:0 | ||||
| 38. Round | 21/05/2022 | Clermont Foot 63 | - | Olympique Lyonnais | 1:2 |
Spain