| 6. Round | 09/01/2021 | Zamalek | - | Tala'ea El Gaish SC | 3:0 | ||||
| 7. Round | 12/01/2021 | Al Masry Club | - | Zamalek | 0:1 | ||||
| 9. Round | 23/01/2021 | Aswan SC | - | Zamalek | 0:0 | ||||
| 10. Round | 28/01/2021 | Zamalek | - | Misr lel-Maqasah SC | 4:1 | ||||
| 11. Round | 02/02/2021 | Ghazl Al Mehalla | - | Zamalek | 2:1 | ||||
| 14. Round | 01/03/2021 | Wadi Degla SC | - | Zamalek | 0:0 | ||||
| 15. Round | 11/03/2021 | Zamalek | - | Ceramica Cleopatra | 2:0 | ||||
| 22. Round | 14/05/2021 | Zamalek | - | ENPPI | 3:1 | ||||
| 23. Round | 20/05/2021 | Zamalek | - | Tala'ea El Gaish SC | 2:1 |  |
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| 24. Round | 24/05/2021 | Zamalek | - | Al Masry Club | 3:2 | ||||
| 25. Round | 30/05/2021 | El Gouna | - | Zamalek | 0:0 |  |
Egypt