| 2. Round | 10/04/2022 | Alfonso Ugarte | - | Unión Comercio | 1:1 | ||||
| 4. Round | 23/04/2022 | Pirata | - | Unión Comercio | 0:2 | ||||
| 5. Round | 01/05/2022 | Unión Comercio | - | Llacuabamba | 2:0 | ||||
| 7. Round | 15/05/2022 | Unión Comercio | - | Santos FC | 3:1 | ||||
| 8. Round | 21/05/2022 | Deportivo Coopsol | - | Unión Comercio | 0:1 | ||||
| 9. Round | 29/05/2022 | Unión Comercio | - | Unión Huaral | 4:0 | ||||
| 10. Round | 05/06/2022 | Juan Aurich | - | Unión Comercio | 2:1 |  |
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| 11. Round | 12/06/2022 | Unión Comercio | - | Alianza Universidad | 3:1 | ||||
| 12. Round | 18/06/2022 | Comerciantes Unidos | - | Unión Comercio | 2:3 |
Peru