| 1. Round | 22/01/2023 | ART Municipal Jalapa | - | Real Estelí FC | 1:1 |  |
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| 2. Round | 29/01/2023 | Real Estelí FC | - | Club Deportivo Ocotal | 3:1 | ||||
| 3. Round | 05/02/2023 | Real Estelí FC | - | H&H Export Sébaco | 0:1 | |
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| 4. Round | 08/02/2023 | CD Walter Ferretti | - | Real Estelí FC | 1:1 | ||||
| 5. Round | 12/02/2023 | Real Estelí FC | - | Juventus Managua | 1:0 | |
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| 6. Round | 16/02/2023 | Real Estelí FC | - | Managua FC | 2:0 | ||||
| 7. Round | 19/02/2023 | Diriangén FC | - | Real Estelí FC | 2:3 | |
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| 9. Round | 05/03/2023 | Real Estelí FC | - | Matagalpa FC | 2:1 | |
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| 10. Round | 10/03/2023 | Real Estelí FC | - | ART Municipal Jalapa | 3:1 | ||||
| 13. Round | 03/04/2023 | Real Estelí FC | - | CD Walter Ferretti | 2:2 | ||||
| 14. Round | 06/04/2023 | Juventus Managua | - | Real Estelí FC | 0:7 | |
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| 15. Round | 13/04/2023 | Managua FC | - | Real Estelí FC | 0:3 | ||||
| 16. Round | 18/04/2023 | Real Estelí FC | - | Diriangén FC | 1:2 | |
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| 18. Round | 23/04/2023 | Matagalpa FC | - | Real Estelí FC | 0:1 |
Nicaragua