| 10. Round | 08/03/2021 | Diriangén FC | - | Chinandega | 3:0 | ||||
| 12. Round | 01/04/2021 | Managua FC | - | Chinandega | 3:1 |  |
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| 13. Round | 11/04/2021 | Chinandega | - | Club Deportivo Ocotal | 2:1 | ||||
| 17. Round | 03/05/2021 | ART Municipal Jalapa | - | Chinandega | 1:1 | ||||
| 18. Round | 05/05/2021 | Chinandega | - | CD Walter Ferretti | 0:3 |
Nicaragua