| 2. Round | 16/07/2022 | Real Cartagena | - | Leones FC | 0:1 | ||||
| 3. Round | 22/07/2022 | Atlético Huila | - | Real Cartagena | 2:3 | ||||
| 4. Round | 29/07/2022 | Real Cartagena | - | Cúcuta Deportivo | 1:2 | ||||
| 6. Round | 07/08/2022 | Fortaleza FC | - | Real Cartagena | 3:1 | ||||
| 7. Round | 17/08/2022 | Real Cartagena | - | Real Santander | 2:2 | ||||
| 8. Round | 24/08/2022 | Boyacá Chicó | - | Real Cartagena | 4:0 |
Colombia