| 8. Round | 12/09/2021 | Luis Ángel Firpo | - | Isidro Metapán | 1:1 | ||||
| 9. Round | 15/09/2021 | Atlético Marte | - | Luis Ángel Firpo | 1:3 | ||||
| 10. Round | 19/09/2021 | Luis Ángel Firpo | - | Santa Tecla FC | 0:0 | ||||
| 11. Round | 26/09/2021 | CD Águila | - | Luis Ángel Firpo | 1:1 | ||||
| 12. Round | 02/10/2021 | Jocoro FC | - | Luis Ángel Firpo | 2:1 | ||||
| 14. Round | 09/10/2021 | Platense Zacatecoluca | - | Luis Ángel Firpo | 1:3 | ||||
| 13. Round | 17/10/2021 | Luis Ángel Firpo | - | Municipal Limeño | 1:1 |  |
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| 16. Round | 31/10/2021 | Luis Ángel Firpo | - | AD Chalatenango | 4:2 | ||||
| 17. Round | 02/11/2021 | Once Municipal | - | Luis Ángel Firpo | 1:0 | |
El Salvador