| 1. Round | 19/07/2014 | CD Veracruz | - | Santos Laguna | 0:1 | ||||
| 2. Round | 26/07/2014 | Santos Laguna | - | Cruz Azul | 1:1 | ||||
| 3. Round | 03/08/2014 | CF Monterrey | - | Santos Laguna | 0:0 | ||||
| 4. Round | 10/08/2014 | Santos Laguna | - | Gallos Blancos | 2:3 | ||||
| 5. Round | 17/08/2014 | Deportivo Guadalajara | - | Santos Laguna | 0:1 | ||||
| 6. Round | 23/08/2014 | Santos Laguna | - | Deportivo Toluca | 3:0 | ||||
| 7. Round | 31/08/2014 | Atlas Guadalajara | - | Santos Laguna | 1:1 | ||||
| 8. Round | 13/09/2014 | Santos Laguna | - | Club León | 2:0 | ||||
| 9. Round | 20/09/2014 | Club Tijuana | - | Santos Laguna | 4:1 | ||||
| 10. Round | 27/09/2014 | Santos Laguna | - | CF América | 1:4 | ||||
| 11. Round | 01/10/2014 | UANL Tigres | - | Santos Laguna | 1:1 | ||||
| 12. Round | 05/10/2014 | Santos Laguna | - | Monarcas Morelia | 2:2 | ||||
| 13. Round | 19/10/2014 | Chiapas FC | - | Santos Laguna | 2:0 | ||||
| 14. Round | 25/10/2014 | Santos Laguna | - | Pumas UNAM | 1:1 | ||||
| 15. Round | 02/11/2014 | Leones Negros | - | Santos Laguna | 1:1 | ||||
| 16. Round | 08/11/2014 | Santos Laguna | - | CF Pachuca | 2:1 | ||||
| 17. Round | 22/11/2014 | Puebla FC | - | Santos Laguna | 3:3 |
Mexico