| 1. Round | 16/07/2021 | River Plate II | - | Colón de Santa Fe II | 1:2 | ||||
| 2. Round | 23/07/2021 | River Plate II | - | Unión de Santa Fe II | 2:0 | ||||
| 3. Round | 27/07/2021 | Lanús II | - | River Plate II | 0:1 | ||||
| 4. Round | 30/07/2021 | River Plate II | - | Huracán II | 2:0 | ||||
| 5. Round | 06/08/2021 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 6. Round | 13/08/2021 | River Plate II | - | Vélez Sarsfield II | 1:2 | ||||
| 7. Round | 19/08/2021 | Gimnasia de La Plata II | - | River Plate II | 3:1 |  |
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| 9. Round | 31/08/2021 | Sarmiento de Junín II | - | River Plate II | 3:1 | ||||
| 10. Round | 06/09/2021 | River Plate II | - | Independiente II | 4:0 | |
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| 11. Round | 10/09/2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Round | 17/09/2021 | River Plate II | - | Arsenal de Sarandí II | 0:1 | ||||
| 13. Round | 24/09/2021 | Central Córdoba SdE II | - | River Plate II | 1:2 | ||||
| 14. Round | 01/10/2021 | River Plate II | - | Boca Juniors II | 0:3 | ||||
| 15. Round | 07/10/2021 | Banfield II | - | River Plate II | 2:0 | ||||
| 24. Round | 03/12/2021 | River Plate II | - | Defensa y Justicia II | 2:1 |
Colombia
Argentina