| 1. Round | 06/08/2021 | US Créteil-Lusitanos | - | US Avranches | 0:0 |  |
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| 6. Round | 10/09/2021 | US Avranches | - | Stade Lavallois | 0:1 | ||||
| 7. Round | 20/09/2021 | US Concarneau | - | US Avranches | 1:3 | ||||
| 8. Round | 24/09/2021 | US Avranches | - | US Boulogne | 1:0 | ||||
| 9. Round | 01/10/2021 | FC Chambly | - | US Avranches | 4:2 | ||||
| 10. Round | 08/10/2021 | US Avranches | - | Red Star FC | 0:6 | |
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| 23. Round | 25/02/2022 | US Avranches | - | US Concarneau | 1:1 | ||||
| 24. Round | 05/03/2022 | US Boulogne | - | US Avranches | 1:2 | ||||
| 25. Round | 11/03/2022 | US Avranches | - | FC Chambly | 1:0 | ||||
| 26. Round | 18/03/2022 | Red Star FC | - | US Avranches | 2:1 |  |
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| 27. Round | 25/03/2022 | US Avranches | - | US Orléans | 1:2 | ||||
| 28. Round | 01/04/2022 | FC Annecy | - | US Avranches | 4:1 | ||||
| 29. Round | 08/04/2022 | US Avranches | - | FC Villefranche Beaujolais | 1:1 | |
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| 30. Round | 15/04/2022 | FC Bastia-Borgo | - | US Avranches | 1:2 | ||||
| 31. Round | 22/04/2022 | US Avranches | - | SO Cholet | 0:2 | ||||
| 32. Round | 29/04/2022 | US Avranches | - | Stade Briochin | 2:5 | |
Morocco