| 1. Round | 16/12/2020 | JS Kairouan | - | Club Africain | 1:2 | ||||
| 3. Round | 20/12/2020 | JS Kairouan | - | Stade Tunisien | 0:4 | ||||
| 2. Round | 23/12/2020 | Olympique Béja | - | JS Kairouan | 1:1 | ||||
| 4. Round | 27/12/2020 | ES Métlaoui | - | JS Kairouan | 2:0 | ||||
| 5. Round | 30/12/2020 | AS Rejiche | - | JS Kairouan | 2:0 | ||||
| 8. Round | 13/01/2021 | JS Kairouan | - | AS Soliman | 2:3 |  |
|||
| 10. Round | 27/01/2021 | JS Kairouan | - | Étoile du Sahel | 1:3 | ||||
| 6. Round | 17/02/2021 | JS Kairouan | - | Espérance de Tunis | 0:3 | ||||
| 14. Round | 27/02/2021 | Club Africain | - | JS Kairouan | 4:2 | ||||
| 15. Round | 03/03/2021 | JS Kairouan | - | Olympique Béja | 0:1 |  |
|||
| 17. Round | 10/03/2021 | JS Kairouan | - | ES Métlaoui | 1:1 | ||||
| 18. Round | 14/03/2021 | JS Kairouan | - | AS Rejiche | 0:1 | |
|||
| 20. Round | 20/03/2021 | JS Kairouan | - | US Monastir | 0:1 | ||||
| 21. Round | 31/03/2021 | AS Soliman | - | JS Kairouan | 2:1 | |
|||
| 23. Round | 07/04/2021 | Étoile du Sahel | - | JS Kairouan | 5:1 | |
|||
| 19. Round | 18/04/2021 | Espérance de Tunis | - | JS Kairouan | 3:1 | ||||
| 24. Round | 05/05/2021 | JS Kairouan | - | CA Bizertin | 1:4 | ||||
| 25. Round | 09/05/2021 | CS Sfaxien | - | JS Kairouan | 2:0 | ||||
| 26. Round | 19/05/2021 | JS Kairouan | - | US Tataouine | 0:1 |
Tunisia