| 3. Round | 28/08/2021 | Flint Town United | - | Aberystwyth Town | 1:0 | ||||
| 4. Round | 31/08/2021 | Aberystwyth Town | - | Bala Town | 0:1 | ||||
| 6. Round | 17/09/2021 | Newtown AFC | - | Aberystwyth Town | 1:2 | ||||
| 7. Round | 01/10/2021 | The New Saints | - | Aberystwyth Town | 3:0 | ||||
| 9. Round | 13/10/2021 | Cefn Druids | - | Aberystwyth Town | 0:1 | ||||
| 13. Round | 09/11/2021 | Aberystwyth Town | - | The New Saints | 1:0 | ||||
| 14. Round | 19/11/2021 | Cardiff Metropolitan | - | Aberystwyth Town | 0:1 | ||||
| 16. Round | 10/12/2021 | Aberystwyth Town | - | Newtown AFC | 2:4 | ||||
| 17. Round | 17/12/2021 | Caernarfon Town | - | Aberystwyth Town | 3:3 | ||||
| 20. Round | 21/01/2022 | Penybont FC | - | Aberystwyth Town | 4:0 | ||||
| 21. Round | 28/01/2022 | Aberystwyth Town | - | Cefn Druids | 5:0 |  |
Wales