| 1. Round | 07/01/2022 | Pumas Tabasco | - | CF Monterrey II | 0:1 |  |
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| 3. Round | 20/01/2022 | Pumas Tabasco | - | TM Fútbol Club | 2:0 | ||||
| 4. Round | 26/01/2022 | Venados FC | - | Pumas Tabasco | 2:2 | |
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| 8. Round | 17/02/2022 | Pumas Tabasco | - | Tapatío | 2:1 |  |
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| 10. Round | 03/03/2022 | Pumas Tabasco | - | Mineros de Zacatecas | 0:5 | ||||
| 14. Round | 26/03/2022 | Cancún FC | - | Pumas Tabasco | 2:2 | ||||
| 15. Round | 31/03/2022 | Pumas Tabasco | - | Correcaminos UAT | 1:2 | ||||
| 16. Round | 05/04/2022 | Alebrijes de Oaxaca | - | Pumas Tabasco | 0:0 | ||||
| 17. Round | 14/04/2022 | Pumas Tabasco | - | Atlético Morelia | 0:1 |
Mexico