| 2. Round | 13/07/2022 | Cortuluá | - | Jaguares de Córdoba | 0:1 | ||||
| 3. Round | 16/07/2022 | Jaguares de Córdoba | - | Deportivo Pasto | 0:1 | ||||
| 4. Round | 26/07/2022 | Patriotas FC | - | Jaguares de Córdoba | 0:0 |  |
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| 5. Round | 30/07/2022 | Jaguares de Córdoba | - | Alianza Petrolera | 2:1 | |
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| 6. Round | 06/08/2022 | Deportes Tolima | - | Jaguares de Córdoba | 2:2 |  |
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| 7. Round | 14/08/2022 | Jaguares de Córdoba | - | Deportivo Pereira | 1:2 | ||||
| 8. Round | 21/08/2022 | Millonarios | - | Jaguares de Córdoba | 2:0 | ||||
| 1. Round | 26/08/2022 | Deportivo Cali | - | Jaguares de Córdoba | 2:2 | |
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| 9. Round | 30/08/2022 | Jaguares de Córdoba | - | Envigado FC | 0:0 | ||||
| 10. Round | 06/09/2022 | Deportivo Pasto | - | Jaguares de Córdoba | 2:1 | ||||
| 11. Round | 11/09/2022 | Jaguares de Córdoba | - | Atlético Nacional | 0:1 | ||||
| 12. Round | 18/09/2022 | Unión Magdalena | - | Jaguares de Córdoba | 1:0 | ||||
| 17. Round | 13/10/2022 | América de Cali | - | Jaguares de Córdoba | 1:1 | ||||
| 18. Round | 17/10/2022 | Jaguares de Córdoba | - | Santa Fe | 2:1 | |
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| 19. Round | 23/10/2022 | Independiente Medellín | - | Jaguares de Córdoba | 0:0 | ||||
| 20. Round | 30/10/2022 | Jaguares de Córdoba | - | Atlético Junior | 0:2 |
Colombia