| 2. Round | 02/09/2012 | Inter | - | AS Roma | 1:3 | ||||
| 3. Round | 16/09/2012 | AS Roma | - | Bologna FC | 2:3 |  |
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| 5. Round | 26/09/2012 | AS Roma | - | Sampdoria | 1:1 | ||||
| 6. Round | 29/09/2012 | Juventus | - | AS Roma | 4:1 | ||||
| 7. Round | 07/10/2012 | AS Roma | - | Atalanta | 2:0 | |
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| 8. Round | 21/10/2012 | Genoa CFC | - | AS Roma | 2:4 | ||||
| 9. Round | 28/10/2012 | AS Roma | - | Udinese Calcio | 2:3 | |
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| 11. Round | 04/11/2012 | AS Roma | - | US Palermo | 4:1 | ||||
| 12. Round | 11/11/2012 | Lazio Roma | - | AS Roma | 3:2 | |
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| 14. Round | 25/11/2012 | Delfino Pescara | - | AS Roma | 0:1 | ||||
| 15. Round | 02/12/2012 | AC Siena | - | AS Roma | 1:3 | |
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| 16. Round | 08/12/2012 | AS Roma | - | ACF Fiorentina | 4:2 | |
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| 17. Round | 16/12/2012 | Chievo Verona | - | AS Roma | 1:0 | ||||
| 20. Round | 13/01/2013 | Calcio Catania | - | AS Roma | 1:0 | ||||
| 21. Round | 20/01/2013 | AS Roma | - | Inter | 1:1 | ||||
| 22. Round | 27/01/2013 | Bologna FC | - | AS Roma | 3:3 |  |
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| 23. Round | 01/02/2013 | AS Roma | - | Cagliari Calcio | 2:4 | |
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| 26. Round | 24/02/2013 | Atalanta | - | AS Roma | 2:3 | ||||
| 29. Round | 17/03/2013 | AS Roma | - | Parma FC | 2:0 | ||||
| 30. Round | 30/03/2013 | US Palermo | - | AS Roma | 2:0 | ||||
| 38. Round | 19/05/2013 | AS Roma | - | SSC Napoli | 2:1 |
Greece