| 2. Round | 12/09/2021 | AEK Larnaca | - | Omonia Nikosia | 2:1 | ||||
| 3. Round | 20/09/2021 | Omonia Nikosia | - | Doxa Katokopias | 2:1 | ||||
| 4. Round | 26/09/2021 | Omonia Nikosia | - | Paphos FC | 1:1 | ||||
| 5. Round | 03/10/2021 | Olympiakos Nikosia | - | Omonia Nikosia | 1:0 | ||||
| 6. Round | 17/10/2021 | Omonia Nikosia | - | Apollon Limassol | 1:0 | ||||
| 7. Round | 25/10/2021 | PAEEK | - | Omonia Nikosia | 1:0 | ||||
| 8. Round | 29/10/2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 |  |
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| 10. Round | 21/11/2021 | Omonia Nikosia | - | Aris Limassol | 3:0 | ||||
| 12. Round | 05/12/2021 | AEL Limassol | - | Omonia Nikosia | 0:1 | ||||
| 15. Round | 05/01/2022 | Paphos FC | - | Omonia Nikosia | 1:1 | ||||
| 22. Round | 25/02/2022 | Omonia Nikosia | - | APOEL Nikosia | 2:4 | |
Cyprus