| 1. Round | 18/07/2021 | Sport Boys | - | Cienciano | 1:4 |  |
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| 2. Round | 24/07/2021 | Ayacucho FC | - | Sport Boys | 1:2 | ||||
| 3. Round | 01/08/2021 | Sport Boys | - | Alianza Lima | 0:0 | |
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| 4. Round | 04/08/2021 | Alianza Universidad | - | Sport Boys | 2:0 | ||||
| 5. Round | 08/08/2021 | Academia Cantolao | - | Sport Boys | 0:2 | |
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| 8. Round | 22/08/2021 | Sport Boys | - | Universitario de Deportes | 0:0 | ||||
| 11. Round | 18/09/2021 | Deportivo Binacional | - | Sport Boys | 1:2 | ||||
| 12. Round | 22/09/2021 | Sport Boys | - | Cusco FC | 3:2 | ||||
| 13. Round | 26/09/2021 | FBC Melgar | - | Sport Boys | 1:0 | |
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| 14. Round | 01/10/2021 | Sport Boys | - | Alianza Atlético | 3:1 | ||||
| 15. Round | 16/10/2021 | Universidad Técnica | - | Sport Boys | 1:1 | ||||
| 16. Round | 22/10/2021 | Sport Boys | - | Mannucci | 3:3 | |
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| 17. Round | 30/10/2021 | Sporting Cristal | - | Sport Boys | 1:1 |
Peru