| 2. Round | 19/08/2000 | RSC Charleroi | - | KRC Harelbeke | 5:0 | ||||
| 3. Round | 27/08/2000 | RSC Charleroi | - | Royal Antwerp FC | 1:0 | ||||
| 4. Round | 05/09/2000 | RSC Anderlecht | - | RSC Charleroi | 7:2 | ||||
| 5. Round | 09/09/2000 | RSC Charleroi | - | Lierse SK (old) | 2:0 | ||||
| 6. Round | 17/09/2000 | KRC Genk | - | RSC Charleroi | 2:1 | ||||
| 8. Round | 29/09/2000 | Excelsior Mouscron | - | RSC Charleroi | 3:0 | ||||
| 9. Round | 14/10/2000 | RSC Charleroi | - | Sporting Lokeren | 1:0 | ||||
| 28. Round | 06/04/2001 | RAA La Louviére | - | RSC Charleroi | 1:1 | ||||
| 29. Round | 14/04/2001 | RSC Charleroi | - | Germinal Beerschot | 2:1 |  |
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| 30. Round | 22/04/2001 | Club Brugge KV | - | RSC Charleroi | 1:0 | ||||
| 31. Round | 28/04/2001 | RSC Charleroi | - | KV Mechelen | 4:2 | |
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| 32. Round | 06/05/2001 | K.S.C. Eendracht Aalst | - | RSC Charleroi | 4:0 | ||||
| 33. Round | 12/05/2001 | RSC Charleroi | - | Sint-Truidense VV | 1:7 | ||||
| 34. Round | 20/05/2001 | KVC Westerlo | - | RSC Charleroi | 0:1 |
France