| 20. Round | 08/01/2022 | RC Lens | - | Stade Rennais | 1:0 | ||||
| 21. Round | 15/01/2022 | AS Saint-Étienne | - | RC Lens | 1:2 | ||||
| 22. Round | 22/01/2022 | RC Lens | - | Olympique Marseille | 0:2 | ||||
| 23. Round | 06/02/2022 | FC Lorient | - | RC Lens | 2:0 | ||||
| 24. Round | 13/02/2022 | RC Lens | - | Girondins Bordeaux | 3:2 | ||||
| 26. Round | 27/02/2022 | Angers SCO | - | RC Lens | 1:2 | ||||
| 27. Round | 05/03/2022 | RC Lens | - | Stade Brestois 29 | 0:1 | ||||
| 28. Round | 13/03/2022 | FC Metz | - | RC Lens | 0:0 | ||||
| 29. Round | 19/03/2022 | RC Lens | - | Clermont Foot 63 | 3:1 | ||||
| 30. Round | 03/04/2022 | RC Strasbourg | - | RC Lens | 1:0 | ||||
| 31. Round | 10/04/2022 | RC Lens | - | OGC Nice | 3:0 | ||||
| 32. Round | 16/04/2022 | Lille OSC | - | RC Lens | 1:2 | ||||
| 33. Round | 20/04/2022 | RC Lens | - | Montpellier HSC | 2:0 | ||||
| 37. Round | 14/05/2022 | ESTAC Troyes | - | RC Lens | 1:3 |
Norway